The aim of the article is to describe the myth of femme fatale. Starting from popular culture and ending with the representatives of archaic cultures, the author tries to indicate the women who are described in patriarchal narratives as those who bring men to defeat and ruin. An important figure for the whole argument is Lilith, who, according to Jewish legends, was the first wife of Adam. Lilith was erased from the biblical tradition because she opposed her partner and turned away from God. She has become the female archetype of sin, the symbol of sexual vampirism and the rejection of motherhood. All these features make up the femme fatale syndrome.